MONDAY, MAY 26

14⁰⁰

Ca_VX Workshop // Ion Channels in Drug Discovery – The Good, The Bad and The Ugly 

Michael LEITNER

16³⁰

Ca_VX Workshop // The use of AI in data analysis and academic writing

Anita E. WEIDMANN and Matteo CESARI

20⁰⁰

WELCOME (Gerald OBERMAIR)

20¹⁵

Opening Plenary Lecture supported by the Austrian Neuroscience Association

CHAIR: Franz HOFMANN

Pascal S. KAESER // Modular and dynamic active zone structure for Ca²⁺-triggering of neurotransmitter release

21¹⁵

WELCOME PARTY

TUESDAY, MAY 27

Voltage-gated calcium channels in disease 1

08²⁰

CHAIR/Perspective: Petronel TULUC

08³⁰

Ivy DICK //Voltage-gated calcium channel dysregulation in calmodulinopathies

08⁵⁰

Peri KURSHAN // Modeling CACNA1A patient variants in C. elegans yields insights into their effect on channel and synapse function

09¹⁰

Raquel MOYA // Dissecting a complex genetic association at the CACNA1C schizophrenia locus

09²⁵

Matej HOTKA // Increased L-type calcium channel-mediated Ca²⁺ influx drives epileptogenesis in primary hippocampal neurons

09⁴⁰

Hami LEE // Translating mouse studies to humans: Characterization of a behavior-specific genomic region in CACNA1C intron 3

09⁵⁵

COFFEE BREAK

10³⁰

Matthias GANGLBERGER // Quantitative proteomics enables the detection of varying severity levels of congenital stationary night blindness type 2 mouse models

10⁴⁵

Jing ZHAI // Caffeine inhibition of L-type calcium channels and its implication on circadian rhythm

11⁰⁰

Plenary Lecture

CHAIR: Thomas GUDERMANN

Bernd FAKLER // Ca²⁺-pumps of the plasma membrane – structural background of their ultrafast transport and control by PIP₂

12⁰⁵

RESEARCH FLASHES A: 5 flashes (3 min + 1 min) CHAIR: Yousra EL GHALEB

12³⁰

LUNCH & LUNCHBREAK

14⁰⁰

POSTER SESSION A & COFFEE

Ca_V1.3 channels at work in neural and cardiac systems

16⁰⁰

CHAIR/Perspective: Stephan LEHNART and Tobias MOSER

16¹⁰

Tina PANGRSIC // Modulation of Ca_V1.3 channel inactivation kinetics by CaBP2 variants

16³⁰

Klara ESCH // Ca_V1.3 and multidomain active zone proteins cluster heterogeneously in the Inner Hair Cells of the Cochlea

16⁴⁵

Matteo MANGONI // The pacemaker L-type Ca_V1.3 channel in the heart

17⁰⁵

Melanie FAURE // L-type Ca_V1.3 (a1D) and hyperpolarisation-activated “funny” (HCN) channels mediate heart rate acceleration by catecholamines

17²⁰

DINNER

Symposium in honor of Bill Catterall

19³⁰

CHAIRS: Johannes HELL and Jörg STRIESSNIG

19⁴⁰

Massimo MANTEGAZZA // Functional analysis and phenotypes of SCN1A/Na_V1.1 variants

20¹⁰

Amy LEE // Ca²⁺ channel switching at the cone photoreceptor synapse

20⁴⁰

Richard TSIEN // Calcium channels link membrane voltage to cell signaling in unexpected ways

21¹⁰

BEER & CHIPS @ POSTERS

WEDNESDAY, MAY 28

Calcium channel regulation – physiological roles

08²⁰

CHAIR/Perspective: Gerald OBERMAIR

08³⁰

Samuel YOUNG // Presynaptic Ca_V2.1 calcium current facilitation is essential for ultrafast computations for accurate auditory information processing

08⁵⁰

Ryuichi SHIGEMOTO // Alternative splicing of P/Q-type voltage-gated calcium channel EF-hands regulates the coupling tightness in parallel fiber-Purkinje cell synapses

09¹⁰

Martin HEINE // Mobile Ca_V2.1 channels facilitate the flexible use of release sites within synapses

09²⁵

Mark DELL’ACQUA // L-type Ca²⁺ channel activation of STIM1-Orai1 signaling remodels the dendritic spine ER to maintain long-term postsynaptic structural plasticity

09⁴⁵

Stefanie GEISLER // Genetic deletion of Stac2 affects electrical activity of chromaffin cells and mouse behavior

10⁰⁰

COFFEE BREAK

Calcium channel regulation – α₂δ proteins

10³⁰

CHAIR/Perspective: Annette DOLPHIN

10⁴⁰

Ivan KADURIN // Uncovering an autoinhibitory domain of α₂δ subunits essential for functional maturation of voltage-gated calcium channels

11⁰⁰

Nils HOHAUS // Neurexin binding dissociates α₂δ auxiliary subunits from voltage-gated calcium channels

11¹⁵

Sabrin HADDAD // α₂δ-2 mutations linked to epileptic encephalopathy affect calcium channels and synapses

11³⁰

Maria ROZNOVCOVA // The MIDAS motif of voltage-gated calcium channel modulator CACHD1 is important for expression and function

11⁴⁵

Peter PENZES // Pro-cognitive reshaping of neuronal dynamics by the human CSF-based factor soluble Cacna2d1

12⁰⁵

RESEARCH FLASHES B: 6 flashes (3 min + 1 min) CHAIR: Xaver KÖNIG

12³⁰

LUNCH & LUNCHBREAK

14⁰⁰

POSTER SESSION B & COFFEE

Ion channel regulation in disease

16⁰⁰

CHAIR/Perspective:  Nadine ORTNER

16¹⁰

Johannes HELL // The L-type Ca²⁺ channel Ca_V1.2 constitutes a molecular locus for sustained attention

16³⁰

Tuck Wah SOONG // Dominant role of smooth muscle galectin-3 in blood pressure regulation by modulating Ca_V1.2 calcium channel function

16⁵⁰

Anouar BELKACEMI // Ca_Vβ3 Contributes to the Maintenance of the Blood-Brain Barrier and Alleviates Symptoms of Experimental Autoimmune Encephalomyelitis

17⁰⁵

Liu CONG // Filamin A modulates Ca_V1.2 Channel Function in Hypertension

17²⁰

DINNER

Special topic: From storage to signal

19⁴⁰

CHAIR/Perspectives: Martin BIEL

19⁵⁰

Christoph BRENKER // Human fertilization in vivo and in vitro requires the CatSper channel to initiate sperm hyperactivation

20¹⁰

Volodymyr TSVILOVSKYY // N6-methyladenosine activates mast cells by stimulation of A3 purinergic receptors, involvement of Gαq/11/PLC signaling pathway and Ca²⁺ entry through Orai1/Orai2 formed channels

20²⁵

Juan TOLEDO-MARCOS // Identification of the STIM1-Orai interaction interface: towards CRAC deSTIMulation

20⁴⁰

Cheng-Chang CHEN // On-Demand Phosphoinositide Activation of TRPML2 Regulates Endosomal Calcium Release and Rab4⁺ Vesicle Trafficking

20⁵⁵

Xaver KÖNIG // Phasic store-operated calcium entry in skeletal muscle

21¹⁰

BEER & CHIPS @ POSTERS

THURSDAY, MAY 29

Special TRR 152 & SFB 1328 Symposium: Ca²⁺ homeostasis regulated by NAADP and endo-lysosomal channels

08²⁰

CHAIR/Perspective: Christian WAHL-SCHOTT

08³⁰

Bo ZENG // Taking breaths with TMEM63 channel: life depends on it

08⁵⁵

Amit AGARWAL // Mechanotransduction channel Tmem63a regulates myelin sheath geometry in the central nervous system

09¹⁰

Andreas GUSE // NAADP and calcium microdomains

09³⁵

Roger OTTENHEIJM // An endo-lysosomal Ca²⁺ store in cardiomyocytes controlled by OCaR proteins determines fatal tachyarrhythmias

09⁵⁰

Katsumori SEGAWA // Phospholipid dynamics in the plasma membrane and its impact on human health

10¹⁵

COFFEE BREAK

TRP channels in immunity, inflammation, and ischemia

10⁵⁰

CHAIR/Perspectives: Marc FREICHEL

11⁰⁰

Christian GRIMM // TRPML channels in lung disease

11²⁰

Micael CUNHA // New strategies to investigate TRPML1 biology in health and tumor cells

11³⁵

Susanna ZIERLER // TRPM7 kinase promotes pathogenic Th17 responses during CNS autoimmunity

11⁵⁵

Lu-Yang WANG // Bilirubin directly activates TRPM2 channels to cause Ca²⁺-dependent cell death in stroke 

12¹⁵

Ivan BOGESKI // The Mitochondrial Calcium Uniporter Controls T-Cell Function and Autoimmune Responses

12³⁵

Michael ZHU // TRPC4 regulation of integrin function and its role in neurodevelopment

12⁵⁵

INDIVIDUAL LUNCH and
AFTERNOON and EVENING ACTIVITIES (Individual dinner)

FRIDAY, MAY 30

Ion channel regulation and disease

08²⁰

CHAIR/Perspective: Nathan DASCAL

08³⁰

Anjali RAJADHYAKSHA  // Cacna1c (Ca_V1.2) and addiction-associated memories

08⁵⁰

Arne MOULD // Characterization of short transcripts arising from the 3’ end of the CACNA1F L-type calcium channel gene

09⁰⁵

Giriraj SAHU // Interdomain π-π and π-H interactions contribute to the Voltage-Dependent Facilitation of L-Type Voltage-Gated Calcium Channels

09²⁵

Mufassra MUSHTAQ // Cardiomyocyte [Na⁺]i elevation and atrial fibrillation in a transgenic mouse model with redox-competent mitochondria induces subcellular membrane remodelling and proteomic defects

09⁴⁰

Robin REQUADT // Robust inference of cooperative behaviour of multiple ion channels in voltage-clamp recordings

09⁵⁵

COFFEE BREAK

Ion channel regulation in disease

10³⁰

CHAIR/Perspective: Stefan HERZIG

10⁴⁰

Rajesh KHANNA // A peptidomimetic modulator of the Ca_V2.2 N-type calcium channel for chronic pain

11⁰⁰

Gerald ZAMPONI // Targeting T-type calcium channel ubiquitination as a therapeutic strategy for pain

11²⁰

Philippe LORY // Electrophysiological and pharmacological classification of pathogenic T-type Ca_V3 variants

11³⁵

Leoš CMARKO // Pharmacological screen of new therapeutically relevant calcium channel modulators

11⁵⁰

Oleksandra TIAPKO // PIP2-mediated regulation of TRPC3 and its emerging link to neurodevelopmental disorders

12¹⁵

RESEARCH FLASHES C: 6 flashes (3 min + 1 min) CHAIR: Stefanie GEISLER

12⁴⁰

LUNCH & LUNCHBREAK

14⁰⁰

POSTER SESSION C & COFFEE

Ion channel structure and function

16⁰⁰

CHAIR/Perspectives: Bernhard FLUCHER

16¹⁰

Antonios PANTAZIS // A rich conformational palette underlies human Ca_V2.1-channel availability

16³⁰

Nieng YAN // From sugar transporters to glycoconjugated ion channels

16⁵⁰

Hugo BIBOLLET // A de novo CACNA1S mutation in cattle reveals insights into congenital myopathy-18 pathophysiology

17⁰⁵

Martin HEISS // Regulation of the voltage-sensing mechanism in the voltage-gated calcium channel Ca_V1.1

17²⁰

Filip VAN PETEGEM // Structural insights into pharmacology and disease mutations of ryanodine receptors

17⁴⁰

DINNER

20⁰⁰

Closing Plenary Lecture

CHAIR: Marta CAMPIGLIO

Daniel MINOR // Electrosome assembly: a first structural view of ion channel biogenesis

21⁰⁰

Closing remarks (Gerald OBERMAIR)

GOODBYE PARTY