TUESDAY, MAY 24

16⁰⁰

Ca_VX/MCBO Workshop Scientific Communication for Junior Researchers

Heike WAMSER

20⁰⁰

WELCOME NOTE (OBERMAIR)

20¹⁵

Opening Plenary Lecture: Steven O. MARX // Fight-or-flight responses require augmentation of calcium influx via Rad phosphorylation

CHAIR: Franz HOFMANN

21¹⁵

WELCOME PARTY

WEDNESDAY, MAY 25

Voltage-gated Ca²⁺ channels in disease

08¹⁵

CHAIR/Perspectives: Jörg STRIESSNIG

08²⁵

Ivy DICK // Overcoming challenges in the treatment of Ca_V1.2 channelopathies

08⁵⁰

Gabriel STÖLTING // Cacna1d^Ile772Met/+ mice are a model of primary aldosteronism, seizures and neurological abnormalities (PASNA) syndrome

09¹⁵

Melanie MARK // Controlling absence seizures from the cerebellar nuclei via activation of the Gq signaling pathway

09³⁰

Manuel NAVEDO // S1928 phosphorylation tunes vascular L-type channel Ca_V1.2 and arterial function during angiotensin II signaling and hypertension

09⁴⁵

Cornelia ABLINGER // Loss of autism-associated α₂δ-3 affects synaptic protein expression, presynaptic function, neuronal excitability, and mouse behavior

10⁰⁰

COFFEE BREAK

Calcium channel regulation

10³⁰

CHAIR/Perspectives: Gerald ZAMPONI

10⁴⁰

Nathan DASCAL // Full reconstitution of the β-adrenergic cascade regulating Ca_V1.2: the role of Rad and direct channel-PKA interaction

11⁰⁵

Manu BEN-JOHNY // Regulation of voltage-gated calcium channel complexes by protein depalmitoylases

11³⁰

Wietske TUINTE // STAC proteins inhibit calcium and voltage dependent inactivation in L-type Ca²⁺ channels

11⁴⁵

Eder GAMBETA // Dysregulation of Ca_V3.2 channel in trigeminal pain

12⁰⁰

SHORT BREAK

12⁰⁵

RESEARCH FLASHES A: 7 flash presentations CHAIR: Jutta ENGEL

12³⁵

LUNCH

14²⁰

POSTER SESSION A & COFFEE

Ion channels in networks of excitable cells

16²⁰

CHAIR/Perspectives: Tina PANGRSIC

16³⁰

Nare KARAGULYAN // Using Ca_V1.3^A749G/A749G mutant mice to understand sound intensity encoding at the first auditory synapse

16⁴⁵

Rohan KAPOOR // Reconstitution of synthetic ribbon-type active zones in a heterologous system: In pursuit of understanding the spatial coupling of calcium channels by the synaptic ribbon

17⁰⁰

Lu-Yang WANG // Facilitation of presynaptic P/Q-type calcium channels dictates the polarity and magnitude of short-term plasticity

17¹⁵

Rosalie DITTRICH // Non-cell-autonomous functions of Ca_V1.2 in pancreatic beta-cell regulation

17³⁰

DINNER

Special topic: Ion channel structure

19⁵⁰

CHAIR/Perspectives: Bernhard FLUCHER

20⁰⁰

Thomas JENTSCH // Molecular identification, structure/function, and physiology of the acid-activated anion channel ASOR

20³⁰

William CATTERALL // Voltage-gated sodium and calcium channels at atomic resolution: structure, function, and pharmacology

21⁰⁰

Nieng YAN // How to lock down a VSD?

21³⁰

Plenary discussion – 

 – followed by BEER & CHIPS & POSTERS

THURSDAY, MAY 26

Ion channels in disease 1

08²⁰

CHAIR/Perspectives: Gerald OBERMAIR

08³⁰

Anjali RAJADHYAKSHA // Learning to Forget: Could neuropsychiatric risk gene cacna1c underlie individual susceptibility to addiction?

08⁵⁵

Annette DOLPHIN // A CACNA2D1 point mutation in the Cache domain of α₂δ-1 leads to loss of function

09²⁰

Bernd FLEISCHMANN // Modulation of the cardiac scar and impact on electrical vulnerability of the heart

09⁴⁵

Susanna ZIERLER // Two-Pore Channels: Regulators of inter-organellar calcium homeostasis, mast cell reactivity and anaphylaxis

10⁰⁰

COFFEE BREAK

TRP channels 1

11⁰⁰

CHAIR/Perspectives: Vladimir CHUBANOV

11¹⁰

Klaus GROSCHNER // Regulatory lipidation of TRPC channels – new insights into structure-function relations

11³⁵

Shmuel MUALLEM // TRPC3 channel gating by lipids requires localization at ER-PM junctions defined by STIM1

12⁰⁰

Katharina ZIMMERMANN // TRPC5 cold sensing: Teeth and beyond

12²⁵

SHORT BREAK

12³⁰

RESEARCH FLASHES B: 7 flash presentations CHAIR: Stefanie GEISLER

13⁰⁰

LUNCH

14⁰⁰

POSTER SESSION B & COFFEE

Two pore channels

16⁰⁰

CHAIR/Perspectives: Martin BIEL

16¹⁰

Michael ZHU // Mechanism of two-pore channel regulation of mTORC1 during macroautophagy

16³⁵

Andreas GUSE // NAADP signaling and calcium microdomains

17⁰⁰

Christian GRIMM // TPC2 modulation rescues lysosomal storage in Mucolipidosis type IV, Niemann-Pick type C1 and Batten disease

17²⁵

Marc FREICHEL // Organellar Ca²⁺ regulators (OCaRs) determining NAADP-mediated Ca²⁺ release from acidic intracellular stores in pancreatic acinar cells and cardiomyocytes

17⁵⁰

DINNER

Ion channel structure and function

19⁴⁰

CHAIR/Perspectives: Marta CAMPIGLIO

19⁵⁰

Riccardo OLCESE // The early molecular transitions governing Ca_V1.1 opening and EC-coupling in skeletal muscle

20¹⁵

Erick HERNANDEZ-OCHOA // Functional site-directed fluorometry of voltage sensor movement of Ca_V1.1 during an action potential in skeletal muscle fibers

20⁴⁰

Filip VAN PETEGEM // Channelopathies at high resolution: a structural investigation of muscle excitation-contraction coupling components

21⁰⁵

Elena LILLIU // On the molecular origin and physiological role of phasic store-operated calcium entry in skeletal muscle

21²⁰

BEER & CHIPS & POSTERS

FRIDAY, MAY 27

TRP channels 2

CHAIR: Andrea FLEIG / Indu AMBUDKAR

08³⁰

Anant PAREKH // Targeting CRAC channels in human disease

08⁵⁵

Indu AMBUDKAR // STIM2 and Ca²⁺ influx in ER-PM junctions

09²⁰

Andrea FLEIG // Crosstalk of magnesium transport and calcium signaling

09⁴⁵

COFFEE BREAK

Special workshop: Ion channel Imaging

10¹⁵

CHAIR/Perspectives: Martin HEINE

10²⁵

Tobias MOSER // Topography of Ca²⁺ channels at the presynaptic active zone

10⁵⁰

Klaus BENNDORF // New tools to study the function of ligand-gated ion channels

11¹⁵

SHORT BREAK

Ion channels in disease 2

11³⁰

Chair/Perspectives: Johannes HELL

11⁴⁰

Philippe LORY // Modeling the aberrant Ca_V3 activity in brain diseases

12⁰⁵

Andrea MARCANTONI // Dysregulation of calcium released from ryanodine receptors induces synaptic impairments during Alzheimer’s disease onset

12²⁰

Maximiliano ZULUAGA-FORERO // Patient derived CACNA1A mutations affect calcium channel localization and synaptic function in an in-vivo model

12³⁵

Jian YANG // Midchannel proteolysis of Ca_V2.1 P/Q-type voltage-gated calcium channel

12⁵⁰

LUNCH (Packed lunch)

AFTERNOON ACTIVITIES (Individual dinner)

18⁰⁰

Ca_VX Workshop for young researchers: Bringing life science ideas into the realm of bioentrepreneurship Andreas LAUSTSEN-KIEL

SATURDAY, MAY 28

Physiological roles of calcium channels 1

08³⁰

CHAIR/Perspectives: Emilio CARBONE

08⁴⁰

Samuel M. YOUNG // Presynaptic Ca_V2 calcium channel subtype abundance, organization, and the regulation of neurotransmitter release

09⁰⁵

Stephanie ECKRICH // Ca_V1.3 calcium channels show slow turnover rates and are critical for transcriptional regulation of BK channel expression in mature cochlear inner hair cells

09²⁰

Anouar BELKACEMI // Role of Ca_Vβ₂ and Ca_Vβ₃ subunits of voltage-gated Ca²⁺ channels in pancreatic β-cells

09⁴⁵

Hartwig SEITTER // A novel Ca_Vβ₂ splice variant with unique properties predominates in the retina

10⁰⁰

COFFEE BREAK

Calcium regulation

10³⁰

CHAIR/Perspectives: Mark DELL’ACQUA

10⁴⁰

Bernd FAKLER // Fast Ca²⁺-transport by PMCA-neuroplastin/basigin complexes

11⁰⁵

Fiona BARTOLI // Endothelial Piezo1 sustains muscle capillary density and contributes to physical activity

11²⁰

Beatrix DIENES // The mechanosensitive Piezo1 channels contribute to the arterial medial calcification

11³⁵

Mehmet KAPLAN // Actions of Ca_V1.1 in the formation of the neuromuscular synapse

11⁵⁰

SHORT BREAK

12⁰⁰

RESEARCH FLASHES C: 7 flash presentations CHAIR: Petronel TULUC

12³⁰

LUNCH

14⁰⁰

POSTER SESSION C & COFFEE

Physiological roles of calcium channels 2

16⁰⁰

CHAIR/Perspectives: Christian WAHL-SCHOTT

16¹⁰

David BEECH // PIEZO1 in cardiovascular health and disease

16³⁵

Rajesh KHANNA // Unlocking Ca_V2.2’s pain potential

17⁰⁰

Noelia JACOBO-PIQUERAS // Molecular mechanisms responsible for the sexual dimorphism in pancreatic β-cell insulin release

17¹⁵

Matteo MANGONI // The “pacemaker” L-type Ca_V1.3 (α1D) calcium channel in heart automaticity

17⁴⁰

DINNER

20⁰⁰

Closing Plenary lecture: Thomas VOETS // TRPM3 – from the sensory nerve endings to the brain CHAIR: Thomas GUDERMANN

21⁰⁰

Closing remarks ( GUDERMANN / FLOCKERZI / OBERMAIR)

GOODBYE PARTY